Histidine Decarboxylase, DOPA Decarboxylase, and Vesicular Monoamine Transporter 2 Expression in Neuroendocrine Tumors: Immunohistochemical Study and Gene Expression Analysis
نویسندگان
چکیده
منابع مشابه
The regulation of histidine decarboxylase gene expression.
Histamine is a biogenic amine, which is involved in a variety of biologic processes comprising inflammation, allergic responses, neurotransmission and regulation of gastric acid secretion. The key enzyme for the generation of histamine is histidine decarboxylase (HDC), which converts the amino acid L-histidine to histamine. In this article, we review the history, biochemistry and molecular biol...
متن کاملControl of histidine decarboxylase gene expression in enterochromaffin-like cells.
The ability of histamine to stimulate gastric acid secretion was recognized over 75 years ago by Popielski [1]. The central importance of this action in the physiological regulation of acid secretion was established with the development of histamine H2 receptor antagonists by Black and colleagues in the early 1970s [2]. There has, however, been intense debate about the precise mechanisms of act...
متن کاملExpression and function of the rat vesicular monoamine transporter 2.
The vesicular monoamine transporters (VMATs) are essential proteins, involved in the storage of monoamines in the central nervous system and in endocrine cells, in a process that involves exchange of 2H(+) with one substrate molecule. The VMATs interact with various native substrates and clinically relevant drugs and display the pharmacological profile of multidrug transporters. Vesicular trans...
متن کاملDifferential and tissue-specific expression of a gene family for tyrosine/dopa decarboxylase in opium poppy.
Two early and potential rate-limiting steps in the biosynthesis of isoquinoline alkaloids, such as morphine and codeine, in opium poppy (Papaver somniferum) involve decarboxylation of L-tyrosine and L-dihydroxyphenylalanine (L-dopa) to yield tyramine and dopamine, respectively. A DNA fragment was amplified by polymerase chain reaction (PCR) using degenerate primers designed to two highly conser...
متن کاملExpression of human chromosome 2 ornithine decarboxylase gene in ornithine decarboxylase-deficient Chinese hamster ovary cells.
Ornithine decarboxylase (ODC) belongs to a multigene family and some of these may very well be nonfunctional (pseudogenes). We isolated an ODC gene from a human chromosome 2-specific library and transfected the gene into ODC-deficient Chinese hamster ovary cells to directly demonstrate that this ODC gene is functional and ODC is essential for cell proliferation. After screening 2.5 X 10(5) plaq...
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ژورنال
عنوان ژورنال: Journal of Histochemistry & Cytochemistry
سال: 2006
ISSN: 0022-1554,1551-5044
DOI: 10.1369/jhc.5a6770.2006